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In Silico Clinical Trials for Cardiovascular Disease
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Publishing pragmatic trials.

Rita H Pickler1, Margaret H Kearney2

  • 1College of Nursing, The Ohio State University, Columbus, OH.

Nursing Outlook
|June 16, 2018
PubMed
Summary
This summary is machine-generated.

Pragmatic clinical trials (PCTs) help bring effective interventions into real-world healthcare. This paper outlines challenges in writing PCT manuscripts and reviews guidelines to aid researchers.

Keywords:
Nursing sciencePragmatic trialsPublication

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Area of Science:

  • Clinical Research
  • Nursing Research
  • Health Services Research

Background:

  • Pragmatic clinical trials (PCTs) are crucial for translating evidence-based interventions into complex clinical settings.
  • PCTs address real-world challenges like patient comorbidities and multiple healthcare providers.
  • Evaluating effectiveness in PCTs can be difficult due to limited data.

Purpose of the Study:

  • To identify and describe the challenges faced by manuscript writers of pragmatic clinical trials.
  • To review existing guidelines and resources that can assist in developing PCT manuscripts.

Main Methods:

  • This paper is a review and discussion of challenges and guidelines for PCT manuscript preparation.
  • It synthesizes information relevant to nurse researchers and other clinical investigators.

Main Results:

  • Manuscript preparation for PCTs is complex due to the inherent complexities and contextual factors of these trials.
  • Various guidelines and resources exist to support researchers in writing PCT manuscripts.

Conclusions:

  • Addressing the challenges in PCT manuscript writing is essential for effective dissemination of research findings.
  • Utilizing available guidelines can improve the quality and clarity of published PCT research.