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Oncolytic Viruses for Multiple Myeloma Therapy

Christine M Calton1, Kevin R Kelly2, Faiz Anwer3

  • 1Division of Translational and Regenerative Medicine, Department of Medicine and The University of Arizona Cancer Center, Tucson, AZ 85724, USA. calton@email.arizona.edu.

Cancers
|June 16, 2018
PubMed

Insights

New oncolytic viruses offer targeted therapy for multiple myeloma (MM) by infecting cancer cells. This approach aims to directly kill cancer cells and stimulate an anti-tumor immune response, addressing unmet needs in MM treatment.

Area of Science:

  • Oncology
  • Virology
  • Immunotherapy

Background:

  • Multiple myeloma (MM) remains largely incurable despite treatment advances.
  • Therapeutic resistance is common in multiple myeloma.
  • Novel therapeutic strategies are urgently required for MM.

Purpose of the Study:

  • To review oncolytic viruses investigated for multiple myeloma therapy.
  • To highlight oncolytic virus agents that have progressed to clinical trials.

Main Methods:

  • Literature review of oncolytic viruses in multiple myeloma research.
  • Focus on agents currently in clinical trials for MM.

Main Results:

  • Oncolytic viruses selectively infect and replicate within cancer cells.
  • Oncolytic therapy induces direct tumor cell lysis.
  • Oncolytic therapy can stimulate a host anti-tumor immune response.

Conclusions:

  • Oncolytic viruses represent a promising therapeutic class for multiple myeloma.
  • Further clinical investigation of oncolytic viruses is warranted for MM treatment.
Keywords:
adenovirusmeasles virusmultiple myelomamyxoma virusoncolytic virotherapyreovirusvaccinia virusvesicular stomatitis virus

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