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Optimization of temporal sampling for 18F-choline uptake quantification in prostate cancer assessment
Xavier Palard-Novello1,2, Anne-Lise Blin3, Florence Le Jeune4,5
1LTSI-UMR1099, Univ Rennes, Inserm, F-35000, Rennes, France. x.palard@rennes.unicancer.fr.
EJNMMI Research
|June 16, 2018
Summary
Optimizing temporal sampling in dynamic 18F-fluoromethylcholine (FCH) PET imaging improves prostate cancer assessment. A two-phase protocol (5-second blood phase, 30-second tissue phase) accurately quantifies FCH uptake, reducing bias in cancer evaluation.
Area of Science:
- Nuclear Medicine
- Medical Imaging
- Oncology
Background:
- Suboptimal temporal sampling of time-activity curves (TAC) in dynamic 18F-fluoromethylcholine (FCH) PET imaging can bias prostate cancer assessment.
- Accurate quantification of FCH uptake is crucial for effective prostate cancer diagnosis and management.
- Dynamic PET imaging requires optimized sampling protocols to ensure reliable quantitative results.
Purpose of the Study:
- To define an optimal temporal sampling protocol for dynamic 18F-fluoromethylcholine (FCH) PET imaging in prostate cancer assessment.
- To evaluate the impact of different temporal sampling strategies on the accuracy of FCH uptake quantification.
- To identify a sampling protocol that minimizes bias and improves the reliability of PET-based prostate cancer evaluation.
Main Methods:
- Compared irreversible and reversible one-tissue compartment models (1T1K+VB and 1T2k+VB) using Akaike information criterion for 37 prostate cancer lesions.
- Simulated 1000 noisy TACs using Monte Carlo methods across seven different temporal sampling protocols.
- Compared K1 values from simulated TACs to a target K1 value derived from an imaging-derived input function for each patient.
Main Results:
- The 1T2k + VB model was selected as the best fit for the data.
- The temporal sampling protocol of 12 frames of 5 seconds followed by 8 frames of 30 seconds (12×5″-8×30″) yielded K1 values closest to the target K1.
- This optimal sampling protocol showed significant differences in K1 values compared to most other tested samplings, validating its accuracy.
Conclusions:
- A two-phase temporal sampling strategy, with an initial 5-second blood phase and a subsequent 30-second tissue phase, is recommended for dynamic FCH PET.
- This optimized protocol enhances the accuracy of TAC quantification for prostate cancer assessment.
- Implementing this sampling strategy can reduce bias and improve the reliability of FCH PET imaging in clinical practice.
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