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Updated: Feb 9, 2026

RNAi Trigger Delivery into Anopheles gambiae Pupae
Published on: March 8, 2016
Delivery of Cargo with a Bioelectronic Trigger
Zahra Hemmatian1, Elmira Jalilian2,3,4, Sangeun Lee
1Department of Electrical Engineering , University of California Santa Cruz , Santa Cruz , California 95064 , United States.
Abstract:
Biological systems exchange information often with chemical signals. Here, we demonstrate the chemical delivery of a fluorescent label using a bioelectronic trigger. Acid-sensitive microparticles release fluorescin diacetate upon low pH induced by a bioelectronic device. Cardiac fibroblast cells (CFs) uptake fluorescin diacetate, which transforms into fluorescein and emits a fluorescent signal. This proof-of-concept bioelectronic triggered delivery may be used in the future for real-time programming and control of cells and cell systems.
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