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Delivery of Cargo with a Bioelectronic Trigger.

Zahra Hemmatian1, Elmira Jalilian2,3,4, Sangeun Lee

  • 1Department of Electrical Engineering , University of California Santa Cruz , Santa Cruz , California 95064 , United States.

ACS Applied Materials & Interfaces
|June 16, 2018
PubMed
Summary

Researchers developed a bioelectronic system to deliver fluorescent labels into cells. This method uses acid-sensitive microparticles triggered by a bioelectronic device to release a compound that fluoresces within cardiac fibroblast cells.

Keywords:
bioelectronicsbiological functioncardiac celldeliverymicroparticle

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Area of Science:

  • Bioelectronics
  • Cellular signaling
  • Biomaterials

Background:

  • Biological systems rely on chemical signals for information exchange.
  • Controlling cellular behavior requires precise delivery of molecular signals.

Purpose of the Study:

  • To demonstrate a novel bioelectronic method for triggered chemical delivery into cells.
  • To establish a proof-of-concept for real-time control of cellular systems using bioelectronic triggers.

Main Methods:

  • Utilized acid-sensitive microparticles loaded with fluorescein diacetate.
  • Employed a bioelectronic device to induce a localized low pH environment.
  • Observed uptake of fluorescein diacetate by cardiac fibroblast cells (CFs) and subsequent conversion to fluorescein.

Main Results:

  • The bioelectronic device successfully triggered the release of fluorescein diacetate from microparticles by inducing low pH.
  • Cardiac fibroblast cells internalized the released fluorescein diacetate.
  • Internalized fluorescein diacetate was converted to fluorescein, resulting in a detectable fluorescent signal within the cells.

Conclusions:

  • This study presents a viable bioelectronic triggered delivery system for chemical signals.
  • The developed system enables real-time monitoring of cellular responses via fluorescence.
  • This technology holds potential for future applications in programming and controlling cells and cell systems.