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ENERGY PROFILE OF RATS WITH OVERACTIVE BLADDER SYNDROME PHARMACOLOGICALLY CORRECTED WITH QUERCETIN
O Iatsyna1, N Diachkova1, M Kharkhota1
11Odessa National Medical University; 2State Institute "Shalimov National Institute of Surgery and Transplantation" of the National Academy of Medical Sciences of Ukraine; 3D.K. Zabolotny Institute of Microbiology and Virology of the NAS of Ukraine, Kyiv, Ukraine.
Georgian Medical News
|June 16, 2018
Summary
Quercetin treatment improved erythrocyte energy metabolism in rats with overactive bladder syndrome. This study reveals Quercetin
Area of Science:
- Biochemistry
- Physiology
- Pharmacology
Background:
- Overactive bladder syndrome is associated with altered erythrocyte adenine nucleotide metabolism.
- Erythrocyte energy profiles are critical indicators of cellular health.
Purpose of the Study:
- To investigate the impact of Quercetin on erythrocyte energy metabolism in a rat model of overactive bladder syndrome.
- To explore Quercetin's potential in correcting metabolic dysfunctions associated with overactive bladder.
Main Methods:
- Induction of overactive bladder syndrome in a rat model.
- Analysis of the adenine nucleotide system in erythrocytes.
- Assessment of erythrocyte energy profiles before and after Quercetin administration.
Main Results:
- Rats with overactive bladder syndrome exhibited a significant decrease in total adenyl nucleotides and ATP concentration.
- Quercetin administration markedly improved the erythrocyte energy profile in these rats.
- Quantitative analysis revealed a restoration of the adenine nucleotide system.
Conclusions:
- Quercetin demonstrates a significant therapeutic effect on erythrocyte energy metabolism in overactive bladder syndrome.
- These findings offer new insights into the pathogenesis of overactive bladder syndrome and potential treatment strategies.
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