Catalytic Lactonization of Unactivated Aryl C-H Bonds with CO2: Experimental and Computational Investigation
Lei Song1, Lei Zhu2, Zhen Zhang1
1Key Laboratory of Green Chemistry & Technology of Ministry of Education, College of Chemistry , Sichuan University , Chengdu 610064 , P. R. China.
Abstract:
The first catalytic lactonization of unactivated aryl C-H bonds with CO2 to afford important phthalides is reported. Notably, this method features high selectivity, excellent functional group tolerance, smooth scalability, and facile product diversification. DFT calculations reveal that a novel insertion of two CO2 into the O-Pd bond of a palladacycle might be the key step, providing great potential and a different perspective for carbonylation with CO2.
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