Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

438
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
438
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

285
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
285
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

343
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
343
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

799
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
799
Inflammatory Response01:28

Inflammatory Response

16.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
16.9K
Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

8.0K
The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
8.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Antiphospholipid Syndrome-Associated Livedoid Vasculopathy Mimicking Recurrent Periprosthetic Joint Infection after Total Knee Arthroplasty: A Case Report.

Journal of orthopaedic case reports·2026
Same author

Sleeve Gastrectomy Versus Banded Roux-en-Y Gastric Bypass for Obesity and Diabetes Mellitus: Psychology and Quality of Life Outcomes at 10 Years.

Obesity surgery·2026
Same author

Do Patients Undergoing Unicompartmental Knee Arthroplasty Who Fail to Achieve Minimal Clinically Important Difference Have Higher Rates of Conversion to Total Knee Arthroplasty?

The Journal of arthroplasty·2026
Same author

How Can Arthroplasty Surgeons Best Use Preoperative Patient-Reported Outcome Measures Across Multiple Domains to Predict Minimal Clinically Important Difference and Patient-Acceptable Symptom State Achievement in Medial Unicompartmental Knee Arthroplasty? Findings From a Prospectively Maintained Multi-Institutional Arthroplasty Registry.

The Journal of arthroplasty·2026
Same author

Association between gastric rhythm and gastroesophageal reflux defined by simultaneous body surface gastric mapping and 24-h pH testing.

American journal of physiology. Gastrointestinal and liver physiology·2025
Same author

Ten‑Year Results of a Randomized Trial Comparing Banded Roux‑en‑Y Gastric Bypass to Sleeve Gastrectomy for Type 2 Diabetes and Weight Loss.

Obesity surgery·2025

Related Experiment Video

Updated: Feb 8, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.0K

Diagnostic inflammatory markers in acute cholangitis.

Andrei M Beliaev1, Michael Booth2, David Rowbotham3

  • 1Green Lane Cardiothoracic Surgical Unit, Auckland City Hospital, Auckland, New Zealand.

The Journal of Surgical Research
|June 17, 2018
PubMed
Summary

Lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP) show greater diagnostic power for acute cholangitis (AC) than white cell count (WCC). These markers can aid in AC diagnosis when WCC is normal.

Keywords:
Acute cholangitisDiagnosisInflammatory biomarkers

More Related Videos

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
08:43

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

10.4K
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

20.8K

Related Experiment Videos

Last Updated: Feb 8, 2026

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
07:22

Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes

Published on: March 7, 2025

1.0K
Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva
08:43

Three-dimensional Inflammatory Human Tissue Equivalents of Gingiva

Published on: April 3, 2018

10.4K
In vivo Imaging Method to Distinguish Acute and Chronic Inflammation
07:10

In vivo Imaging Method to Distinguish Acute and Chronic Inflammation

Published on: August 16, 2013

20.8K

Area of Science:

  • Gastroenterology
  • Clinical Diagnostics
  • Biomarker Research

Background:

  • The 2018 Tokyo guidelines for acute cholangitis (AC) utilize white cell count (WCC) for diagnosis.
  • Current guidelines lack guidance for AC patients presenting with normal WCC.
  • The diagnostic value of alternative inflammatory biomarkers for AC remains undetermined.

Purpose of the Study:

  • To evaluate the diagnostic discriminative powers of common inflammatory markers compared to WCC for AC.
  • To determine optimal diagnostic cutoff levels for these inflammatory markers in AC.

Main Methods:

  • A retrospective cohort study was conducted.
  • Data from 96 patients undergoing endoscopic biliary decompression were analyzed over two years.
  • Thirty-four AC patients and 18 controls meeting eligibility criteria were included.

Main Results:

  • Lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), and C-reactive protein (CRP) demonstrated the highest discriminative powers for diagnosing AC.
  • Optimal cutoff values were identified: WCC ≥ 9.6 × 10⁹/L, neutrophil count ≥ 4.9 × 10⁹/L, lymphocyte count ≤ 1.3 × 10⁹/L, NLR ≥ 5.3, albumin ≤ 30.5 g/L, and CRP ≥ 23.5 mg/L.

Conclusions:

  • Lymphocyte count, NLR, and CRP possess superior diagnostic capabilities compared to WCC, albumin, and neutrophil count for AC.
  • These biomarkers can serve as valuable tools in the diagnosis of acute cholangitis.