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Lipid Droplet Metabolism during Dengue Virus Infection
1Department of Microbiology, The University of Chicago, Chicago, IL 60637, USA.
Trends in Microbiology
|June 18, 2018
Abstract:
Dengue virus (DENV) induces a proviral selective autophagy targeting lipid droplets, termed lipophagy, that stimulates lipid metabolism. Zhang et al. gained mechanistic insight into this process, demonstrating that DENV NS4A/B binds unmodified AUP1 and promotes its translocation from lipid droplets to autophagosomes to drive the induction of lipophagy.
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