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Odor-dependent temporal dynamics in Caenorhabitis elegans adaptation and aversive learning behavior
Jae Im Choi1, Hee Kyung Lee1,2, Hae Su Kim1
1Division of Biological Science and Technology, Yonsei University, Wonju, Gangwondo, South Korea.
Peerj
|June 19, 2018
Summary
The nematode Caenorhabditis elegans adjusts learning speed based on specific odors. This timing correlates with the nuclear accumulation of a key protein in sensory neurons, suggesting a mechanism for memory formation.
Area of Science:
- Neuroscience
- Animal Behavior
- Molecular Biology
Background:
- Animals form learned associations and memories to environmental cues.
- The nervous system maintains cue-specific learning.
- The nematode Caenorhabditis elegans uses the AWC sensory neuron and cGMP-dependent protein kinase EGL-4 for odor adaptation and learning.
Purpose of the Study:
- To investigate if C. elegans adjusts the temporal dynamics of adaptation and aversive learning based on specific odors.
- To explore the role of the AWC neuron and EGL-4 in odor-specific learning timing.
- To establish C. elegans as a model for studying the timing of memory formation.
Main Methods:
- Identified 17 attractive odors for C. elegans, with most requiring the AWC neuron for sensation.
- Developed a novel assay to track odor-guided behavior over time in a single animal population.
- Assessed temporal dynamics of adaptation and aversive learning for 13 odors and EGL-4 localization in the AWC neuron.
Main Results:
- Behavioral changes in response to odors occurred at different times, with some early and others late.
- The timing of behavioral changes correlated with the timing of EGL-4 nuclear accumulation in the AWC neuron.
- The majority of tested odors required the AWC primary sensory neuron for sensation.
Conclusions:
- C. elegans exhibits odor-specific temporal dynamics in adaptation and aversive learning.
- Temporal changes in behavior are likely mediated by aversive learning mechanisms involving EGL-4.
- C. elegans provides a valuable model for studying the timing of memory formation to diverse sensory cues.
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