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Updated: Feb 8, 2026

Temperature-programmed Deoxygenation of Acetic Acid on Molybdenum Carbide Catalysts
Published on: February 7, 2017
Tandem Reactivity of a Self-Assembled Cage Catalyst with Endohedral Acid Groups
Lauren R Holloway1, Paul M Bogie1, Yana Lyon1
1Department of Chemistry , University of California-Riverside , Riverside , California 92521 , United States.
Abstract:
Self-assembly of a carboxylic acid-containing ligand into an Fe4L6 iminopyridine cage allows endohedral positioning of the acid groups while maintaining a robust cage structure. The cage is an effective supramolecular catalyst, providing up to 1000-fold rate enhancement of acetal solvolysis. This enhanced reactivity allows a tandem deprotection/cage-to-cage interconversion that cannot be achieved with other acid catalysts. The combination of rate enhancements and sequestration of the reactive function confers both activity and selectivity on the process, mimicking enzymatic behavior.
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