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Role of the TRPM4 Channel in Cardiovascular Physiology and Pathophysiology

Chen Wang1, Keiji Naruse2, Ken Takahashi3

  • 1Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8558, Japan. wangchen11228@gmail.com.

Cells
|June 20, 2018
PubMed

Insights

The transient receptor potential cation channel subfamily M member 4 (TRPM4) is vital for calcium balance and cardiovascular health. This review explores TRPM4

Area of Science:

  • Cardiovascular Physiology
  • Ion Channel Function
  • Molecular Medicine

Background:

  • Transient receptor potential cation channel subfamily M member 4 (TRPM4) regulates calcium homeostasis.
  • TRPM4 channels are implicated in physiological processes including insulin secretion and immune response.
  • Dysfunction of TRPM4 channels is linked to cardiac conduction disease.

Purpose of the Study:

  • To review the physiological functions of the TRPM4 channel.
  • To assess the role of TRPM4 in cardiovascular pathophysiology.
  • To explore TRPM4's involvement in cardiac ischemia-reperfusion injury.

Main Methods:

  • Literature review of TRPM4 channel research.
  • Analysis of studies on TRPM4 mutations and cardiovascular disease.
  • Synthesis of current knowledge on TRPM4's physiological and pathological roles.

Main Results:

  • TRPM4 is a calcium-activated, selective cation channel crucial for cellular functions.
  • TRPM4 mutations are associated with cardiac conduction abnormalities.
  • Emerging evidence suggests TRPM4 involvement in myocardial infarction via ischemia-reperfusion injury.

Conclusions:

  • TRPM4 plays a significant role in maintaining cardiovascular homeostasis.
  • Understanding TRPM4's function is critical for addressing cardiovascular diseases.
  • TRPM4 represents a potential therapeutic target for managing myocardial infarction.

Keywords:
TRPM4 channelcardiovascular systempathophysiologyphysiology

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