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Updated: Feb 8, 2026

Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain
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Purification and Aggregation of the Amyloid Precursor Protein Intracellular Domain

Published on: August 28, 2012

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Neuregulin 1 regulates amyloid precursor protein cell surface expression and non-amyloidogenic processing

Young-Jung Kim1, Ji-Young Yoo1, Ok-Soon Kim1

  • 1Department of Anatomy and Neuroscience, College of Medicine, Eulji University, Daejeon, 34824, Republic of Korea.

Journal of Pharmacological Sciences
|June 20, 2018
PubMed
Summary

Neuregulin 1 (NRG1) boosts cell surface amyloid precursor protein (APP) levels and promotes its non-amyloidogenic processing in neurons. This suggests NRG1 may play a role in mitigating Alzheimer

Keywords:
ADAM10Amyloid-precursor proteinNeuregulin 1Non-amyloidogenic processingSecreted APPα

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