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Updated: Feb 8, 2026
07:20
Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium
Published on: April 9, 2019
9.8K
Commensal pathogen competition impacts host viability
David Fast1, Benjamin Kostiuk1, Edan Foley2
1Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2S2, Canada.
Summary
Vibrio cholerae
Area of Science:
- Microbiology
- Pathogenesis
- Bacterial Interactions
Background:
- The structure and regulation of the type-six secretion system (T6SS) in Vibrio cholerae are well-studied.
- The role of T6SS in V. cholerae pathogenesis and interactions with host commensals in vivo remains unclear.
Purpose of the Study:
- To investigate the contribution of T6SS to V. cholerae pathogenesis using a Drosophila melanogaster model.
- To elucidate the role of T6SS in V. cholerae interactions with host commensal bacteria during infection.
Main Methods:
- Utilized the Drosophila melanogaster model to study V. cholerae pathogenesis.
- Manipulated T6SS activity and commensal bacterial populations in vivo.
- Assessed disease severity and host immune responses.
Main Results:
- T6SS plays a crucial role in V. cholerae pathogenesis by targeting commensal bacteria.
- Inactivation of T6SS or removal of commensals attenuated disease severity.
- Reintroduction of Acetobacter pasteurianus restored T6SS-dependent pathogenesis.
Conclusions:
- T6SS in V. cholerae acts on commensal bacteria to promote pathogenesis.
- Host immune responses and T6SS collaboratively regulate host viability during infection.
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