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Related Experiment Video

Updated: Feb 8, 2026

Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
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Ventral striatal dysfunction in cocaine dependence - difference mapping for subregional resting state functional

Sheng Zhang1, Chiang-Shan R Li2,3,4

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Researchers found distinct patterns of altered brain connectivity in the ventral striatum (VS) of individuals with cocaine dependence (CD). These subregional changes in functional connectivity offer new insights into brain circuitry deficits in addiction.

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Area of Science:

  • Neuroscience
  • Addiction Research
  • Brain Imaging

Background:

  • Dopaminergic deficits in cocaine dependence (CD) are often studied in the ventral striatum (VS).
  • Altered resting-state functional connectivity (rsFC) is a known characteristic of CD.
  • The VS has functional subregions, requiring detailed analysis for accurate understanding of connectivity changes.

Purpose of the Study:

  • To delineate subregional functional connectivity alterations within the VS in individuals with cocaine dependence compared to healthy controls.
  • To identify distinct patterns of rsFC associated with specific VS subregions in CD.
  • To explore the relationship between these altered connectivity patterns and clinical factors in CD.

Main Methods:

  • Parcellation of the ventral striatum (VS) based on whole-brain rsFC differences between cocaine-dependent (CD) individuals and healthy controls (HC).
  • Identification of functional clusters representing VS subregions (daVS, dpVS, vVS).
  • Correlation analysis of rsFC patterns with cocaine use, craving, depression, and anxiety in CD.

Main Results:

  • The VS was divided into three subregions: dorsal-anterior VS (daVS), dorsal posterior VS (dpVS), and ventral VS (vVS).
  • All three subregions showed reduced rsFC with the hippocampal/parahippocampal gyri (HG/PHG) in CD compared to HC.
  • Distinct changes included reduced vVS rsFC with the ventromedial prefrontal cortex (vmPFC) and increased daVS rsFC with the visual cortex in CD.
  • daVS visual cortical connectivity correlated positively with cocaine use and craving.
  • vVS vmPFC connectivity correlated negatively with depression and anxiety.

Conclusions:

  • Cocain dependence is associated with distinct patterns of altered ventral striatum subregional rsFC.
  • These subregional changes provide a more nuanced understanding of functional dysconnectivity in CD than analyses of the entire VS.
  • The findings offer potential new insights into VS circuit deficits in cocaine dependence and a framework for studying other mental illnesses.