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Author Spotlight: Challenges in Developing Dry Eye Animal Models and Future Research Directions
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Age-Related Dry Eye Lactoferrin and Lactobionic Acid
Dario Rusciano1, Salvatore Pezzino1, Melania Olivieri1
1Sooft Italia SpA, Catania, Italy.
Ophthalmic Research
|June 20, 2018
Summary
Dry eye disease, more common in women and older adults, stems from tear film instability. Lactoferrin and lactobionic acid show promise for treating age-related dry eye.
Area of Science:
- Ophthalmology
- Biochemistry
Background:
- Dry eye disease is a prevalent ocular surface pathology.
- Tear film instability, caused by reduced aqueous or lipid components, characterizes dry eye.
- Dry eye prevalence increases with age and is higher in women.
Purpose of the Study:
- To investigate potential remedies for age-related dry eye.
- To explore the role of lactoferrin and its mimetic, lactobionic acid, in addressing dry eye etiology.
Main Methods:
- Literature review on dry eye pathophysiology.
- Analysis of lactoferrin and lactobionic acid functions related to tear film components.
Main Results:
- Dry eye is linked to decreased tear film stability.
- Age and sex are significant factors in dry eye prevalence.
- Lactoferrin and lactobionic acid present potential therapeutic benefits.
Conclusions:
- Age-related dry eye warrants targeted therapeutic strategies.
- Lactoferrin and lactobionic acid may offer a novel approach to managing dry eye.
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