Role of papilloma virus in proliferative squamous lesions

HPVs are associated with a variety of proliferative squamous lesions. 27 different types of HPV have been identified by DNA molecular hybridization studies. Genus- and type-specific HPV structural antigens can be detected in approximately half of benign warts and condylomata by immunocytochemistry; positive lesions are considered infectious. Genus- and type-specific putative HPV DNA sequences replicating as episomes can be recovered from the majority of benign (exophytic and flat condylomata) and malignant squamous lesions of the cervix and anogenital area. The type of HPV determines, in part, the anatomic site, clinical appearance, and natural history (including potential malignant conversion) of the lesion.