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Screening for coeliac disease in children
Laura Kivelä1,2, Kalle Kurppa1,3
1Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Tampere, Finland.
Acta Paediatrica (Oslo, Norway : 1992)
|June 20, 2018
Summary
Screening children and adolescents for coeliac disease (an autoimmune disorder) may improve diagnosis, especially in at-risk groups. However, widespread population screening is not yet recommended due to ongoing research needs.
Area of Science:
- Pediatric Gastroenterology
- Immunology
- Public Health
Background:
- Coeliac disease is a prevalent gastrointestinal condition in children, often underdiagnosed.
- Untreated coeliac disease can lead to severe long-term health complications.
- Incidence and diagnosis rates have risen significantly in recent decades.
Purpose of the Study:
- To review current concepts regarding coeliac disease screening in pediatric and adolescent populations.
- To evaluate the effectiveness and recommendations for coeliac disease screening strategies.
Main Methods:
- A non-systematic literature review was performed.
- Included studies published from the year 2000 onwards focusing on coeliac disease screening.
Main Results:
- Screening at-risk groups or the general population could enhance diagnostic yield but remains controversial.
- Screening specific high-risk pediatric groups shows potential benefit.
- Untargeted mass screening is not currently advised.
Conclusions:
- Moderate evidence supports screening specific at-risk groups for coeliac disease in children.
- Further research is necessary to validate benefits before recommending large-scale population screening.
- The balance between early diagnosis benefits and lifelong dietary adherence challenges, particularly for asymptomatic individuals, requires further clarification.
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