[The relationship between viral infection and nasal polyps:A Meta-analysis]

Objective:The relationship between viral infection and the occurrence of nasal polyps was explored to help us understand the etiology and pathogenesis of nasal polyps, and to provide scientific basis for the prevention and treatment of nasal polyps through a Meta-analysis. Method:By searching Pubmed, Embase, Web of Science, Cochrane Library, CNKI, Wanfang Database, and VIP Database, time starts from database building until January 1, 2018, a comprehensive case-control study on the relationship between human papillomavirus, Epstein-Barr virus (EBV), respiratory virus infection and nasal polyps published at home and abroad has been conducted. At the same time, relevant literature references have been included and the full texts have been obtained. Stata 12.0 analysis software was used to perform statistical processing on each original data.Odds ratios (OR) and their 95% confidence interval (CI) were adopted to assess the strength of association. Result:21 articles with 24 studies were included on the relationship between HPV, EBV, respiratory viral infection and nasal polyps. The Meta-analysis results showed that the OR of HPV infection and nasal polyps was 6.74, 95%CI was 2.50－18.20, P<0.001, the OR of EBV and nasal polyps was 5.15, 95%CI was 1.66－16.02, P=0.005, the OR of respiratory viruses and nasal polyps was 1.68, 95%CI was 0.93－3.03, P=0.087.There was no significant publication bias in all of the comparisons. Conclusion:HPV and EBV infection were closely associated with the nasal polyps. Respiratory viral infection was not associated with the nasal polyps. Viral infection may be one of the etiologies of nasal polyps. It plays an important role in the pathogenesis of nasal polyps. The prevention and treatment of the virus infection should be targeted at early intervention.