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[The relationship between viral infection and nasal polyps:A Meta-analysis]
1China Medical University,Liaoning Provincial Education Department, Shenyang,110001,China.
Summary
Human papillomavirus (HPV) and Epstein-Barr virus (EBV) infections are strongly linked to nasal polyps. Respiratory viral infections, however, show no significant association with nasal polyp development.
Area of Science:
- Otolaryngology
- Virology
- Epidemiology
Background:
- Nasal polyps are inflammatory masses in the nasal cavity.
- The etiology and pathogenesis of nasal polyps are not fully understood.
- Viral infections are suspected contributors to nasal polyp development.
Purpose of the Study:
- To investigate the association between viral infections and nasal polyps.
- To provide a scientific basis for preventing and treating nasal polyps.
Main Methods:
- A comprehensive meta-analysis of case-control studies.
- Searched multiple databases (PubMed, Embase, Web of Science, etc.) up to January 1, 2018.
- Analyzed data using Stata 12.0, calculating Odds Ratios (OR) and 95% Confidence Intervals (CI).
Main Results:
- Included 21 articles (24 studies) examining human papillomavirus (HPV), Epstein-Barr virus (EBV), and respiratory viruses.
- HPV infection showed a strong association with nasal polyps (OR = 6.74, 95% CI: 2.50–18.20, P<0.001).
- EBV infection also demonstrated a significant association (OR = 5.15, 95% CI: 1.66–16.02, P=0.005).
- Respiratory viruses did not show a significant association (OR = 1.68, 95% CI: 0.93–3.03, P=0.087).
- No significant publication bias was detected.
Conclusions:
- HPV and EBV infections are closely linked to the development of nasal polyps.
- Respiratory viral infections are not significantly associated with nasal polyps.
- Viral infections, particularly HPV and EBV, may play a role in the etiology and pathogenesis of nasal polyps, suggesting targeted early intervention.
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