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In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Effect of radial shock wave therapy on long bone fracture repair.

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Author Spotlight: Effectiveness of Extracorporeal Shockwave Therapy in Achilles Tendinopathy Treatment
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VEGF-A expression in soft tissues repaired by shockwave therapy: differences between modalities.

T Schnurrer-Luke-Vrbanic1, V Avancini-Dobrovic1, I Sosa2

  • 1University Hospital Centre Rijeka, Department of Physical and Rehabilitation Medicine, Rijeka, Croatia.

Journal of Biological Regulators and Homeostatic Agents
|June 21, 2018
PubMed
Summary
This summary is machine-generated.

Shockwave therapy aids long bone fracture healing. Radial shockwave therapy showed stronger stimulation of healing processes, evidenced by increased vascularization and VEGF-A positivity in rat models.

Area of Science:

  • Biomedical Engineering
  • Orthopedic Research
  • Regenerative Medicine

Background:

  • Shockwave therapy is utilized for musculoskeletal conditions like fractures and tendinitis.

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  • Focused shock waves offer adjustable penetration depth and concentrated energy.
  • The efficacy of radial shockwave therapy in deep tissue healing remains under investigation.