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Classes, Databases, and Prediction Methods of Pharmaceutically and Commercially Important Cystine-Stabilized Peptides
S M Ashiqul Islam1, Christopher Michel Kearney2, Erich Baker3,4
1Institute of Biomedical Studies, Baylor University, Waco, TX 76798, USA. S_islam@baylor.edu.
Toxins
|June 21, 2018
Summary
Cystine-stabilized peptides are structurally stable with antimicrobial and insecticidal properties. This review details their subfamilies, resources, and commercial applications as alternatives to antibiotics and insecticides.
Area of Science:
- Biochemistry
- Peptide Science
- Antimicrobial Research
Background:
- Cystine-stabilized peptides are a diverse group known for structural stability and biological activities (bactericidal, fungicidal, insecticidal).
- They are found across various taxa and can be classified by cystine bonding patterns, tertiary structures, and origin.
- Annotation of these peptides is challenging, leading to under-representation in scientific literature.
Purpose of the Study:
- To review the current understanding of cystine-stabilized peptide biology.
- To describe the distinct subfamilies within this peptide family.
- To identify relevant databases and analytical tools for studying these peptides.
- To highlight the commercial applications and success of cystine-stabilized peptides.
Main Methods:
- Literature review of scientific publications.
- Analysis of existing databases and bioinformatics tools.
- Compilation of data on peptide classification and properties.
- Assessment of commercial products and their market impact.
Main Results:
- Cystine-stabilized peptides exhibit diverse properties and can be subclassified based on structural and genetic features.
- Databases and analytical tools are emerging to aid in the identification and prediction of new peptide members.
- Several cystine-stabilized peptides have achieved commercial success as alternatives to traditional antibiotics and insecticides.
Conclusions:
- Further research and improved analytical methods are crucial for discovering new cystine-stabilized peptides.
- These peptides hold significant potential as environmentally friendly and effective alternatives in medicine and agriculture.
- Enhanced data resources and tools will accelerate the development and application of this important peptide family.
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