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St. Jude Cloud: A Pediatric Cancer Genomic Data-Sharing Ecosystem
Clay McLeod1, Alexander M Gout1, Xin Zhou1
1Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.
Cancer Discovery
|January 7, 2021
Summary
St. Jude Cloud offers a free, cloud-based platform with over 1.2 petabytes of genomic data from pediatric cancer patients. This resource accelerates research for better diagnostics and treatments for childhood diseases.
Area of Science:
- Genomics
- Bioinformatics
- Pediatric Oncology
Background:
- Effective data sharing is crucial for advancing pediatric cancer research.
- Genomic data holds potential for improving diagnostic precision, treatment efficacy, and survival rates.
Purpose of the Study:
- To introduce St. Jude Cloud, a cloud-based data-sharing ecosystem.
- To provide access to and facilitate analysis of large-scale pediatric genomic data.
Main Methods:
- Developed a cloud-based ecosystem (St. Jude Cloud) with over 1.25 petabytes of harmonized genomic data.
- Integrated three interconnected apps: Genomics Platform, Pediatric Cancer Knowledgebase, and Visualization Community.
- Utilized gene expression profiling and mutational signature mapping for use cases.
Main Results:
- Freely available genomic data from >10,000 pediatric cancer patients/survivors and >800 sickle cell patients.
- Includes 12,104 whole genomes, 7,697 whole exomes, and 2,202 transcriptomes.
- Demonstrated value through classification of 135 pediatric cancer subtypes and mapping of mutational signatures across 35 subtypes.
Conclusions:
- St. Jude Cloud accelerates pediatric cancer research by providing extensive genomic data and analysis tools.
- The ecosystem enhances the Pediatric Cancer Knowledgebase and supports collaborative research.
- Facilitates advanced data analysis and multiomics visualizations for improved understanding of childhood diseases.
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