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Updated: Feb 8, 2026
09:34
An Automated Culture System for Use in Preclinical Testing of Host-Directed Therapies for Tuberculosis
Published on: August 16, 2021
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Host-targeted therapy for tuberculosis: Time to revisit the concept
Prabha Desikan1, Aseem Rangnekar1
1Department of Microbiology, National Reference Laboratory for Tuberculosis, Bhopal Memorial Hospital & Research Centre, Bhopal, India.
The Indian Journal of Medical Research
|June 21, 2018
Summary
Host-targeted therapy offers a promising strategy to combat drug-resistant tuberculosis (TB). This approach may provide a new avenue for treating multidrug-resistant and extensively drug-resistant TB effectively.
Area of Science:
- Microbiology
- Infectious Diseases
- Pharmacology
Background:
- Tuberculosis (TB) remains a significant global health challenge, causing substantial morbidity and mortality worldwide.
- The increasing prevalence of drug-resistant TB strains, including multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) forms, severely impedes effective treatment and control efforts.
- The slow pace of new anti-tubercular drug discovery, relative to the rapid spread of resistance, necessitates alternative therapeutic strategies.
Purpose of the Study:
- To review the emerging concept of host-targeted therapy as a potential solution for drug-resistant tuberculosis.
- To explore how modulating the host's immune response can complement traditional anti-TB treatments.
- To highlight host-directed strategies as a ray of hope for managing and controlling MDR-TB and XDR-TB.
Main Methods:
- This review synthesizes current scientific literature on host-targeted therapy for TB.
- It examines preclinical and clinical studies investigating host-directed immune response modulation.
- The review analyzes the potential mechanisms and therapeutic benefits of targeting host pathways in TB treatment.
Main Results:
- Host-targeted therapies aim to enhance the host's immune system to clear Mycobacterium tuberculosis more effectively.
- These strategies may overcome existing drug resistance mechanisms by not directly targeting the bacteria.
- Early research suggests that host-directed approaches can be effective in reducing bacterial load and improving treatment outcomes in preclinical models.
Conclusions:
- Host-targeted therapy represents a novel and promising paradigm for the management of drug-resistant TB.
- This approach offers a potential complementary strategy to conventional anti-TB drugs, especially in the face of rising resistance.
- Further research and clinical trials are crucial to fully establish the efficacy and safety of host-directed therapies for TB control.
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