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Updated: Feb 8, 2026

Bioassays for Monitoring Insecticide Resistance
Published on: December 30, 2010
Synthesis and insecticidal activity study of novel anthranilic diamides analogs containing a diacylhydrazine bridge
Yunyun Zhou1, Wei Wei2, Liangliang Zhu1
1State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Yangpu District, Shanghai, China.
Abstract:
Anthranilic diamides is a class of insecticides target at ryanodine receptors (RyRs). To discover potent insecticides targeting at RyRs, a series of novel anthranilic diamides with a diacylhydrazine bridge were designed and synthesized. Their insecticidal activities were evaluated and a preliminary structure-activity relationship (SAR) was summarized. In particular, compound 5g exhibited good lethality against oriental armyworm (Mythimna separata) at a concentration of 5 mg/L. The calcium imaging experimental results indicated that the compound 5g can serve as effective insect Ca2+ level modulators by disrupting the cellular calcium homeostasis in Mythimna separata (Walker) and Spodoptera exigua (Hübner), which probably activated the RyRs on the ER membrane.
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