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[Biological aspects and clinical application of bone-marrow stem cells in critical lower limb ischaemia]

P Iu Orekhov1, A V Troitskiĭ1, A V Chupin1

  • 1Vascular Surgery Department, Federal Scientific Clinical Centre of Specialized Types of Medical Care and Medical Technologies under the Federal Biomedical Agency of Russia, Moscow, Russia.

Angiologiia I Sosudistaia Khirurgiia = Angiology and Vascular Surgery
|June 21, 2018
PubMed

Insights

Critical lower-limb ischaemia (CLLI) treatment shows promise with cell therapy (CT) using bone marrow stem cells (BMSCs). This review explores BMSCs

Area of Science:

  • Regenerative Medicine
  • Vascular Biology
  • Stem Cell Therapy

Background:

  • Critical lower-limb ischaemia (CLLI) presents significant risks, including limb loss and mortality, often unresponsive to conventional treatments.
  • The core pathology of CLLI involves a critical mismatch between tissue oxygen supply and metabolic demand.
  • Current therapeutic options for CLLI are frequently limited in efficacy or applicability.

Purpose of the Study:

  • To review the current understanding of bone marrow stem cells (BMSCs) biology in the context of regenerative medicine.
  • To assess the safety profile of cell therapy (CT) for treating critical lower-limb ischaemia.
  • To evaluate the efficacy of CT utilizing BMSCs in managing CLLI.

Main Methods:

  • Review of existing scientific literature on BMSC biology and their application in CLLI.
  • Analysis of safety data from clinical studies involving cell therapy for critical lower-limb ischaemia.
  • Synthesis of reported outcomes from studies investigating BMSC-based treatments for CLLI.

Main Results:

  • Bone marrow stem cells (BMSCs) offer a promising strategy for stimulating neovascularization and promoting molecular-cellular repair in ischaemic tissues.
  • Accumulated evidence suggests that cell therapy (CT) using BMSCs is relatively safe for treating critical lower-limb ischaemia.
  • Variability in study outcomes is attributed to differences in CT protocols and application methods.

Conclusions:

  • Cell therapy with bone marrow stem cells (BMSCs) represents a novel and potentially effective therapeutic approach for critical lower-limb ischaemia (CLLI).
  • Further research is warranted to optimize CT protocols and standardize application methods to maximize treatment efficacy for CLLI.
  • BMSC-based regenerative medicine holds significant promise for improving outcomes and quality of life in patients with critical lower-limb ischaemia.

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