Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chromatin Packaging02:21

Chromatin Packaging

22.3K
Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
22.3K
Chromatin Packaging01:32

Chromatin Packaging

19.4K
Each human somatic cell contains 6 billion base pairs of DNA. Each base pair is 0.34 nm long, meaning each diploid cell contains a staggering 2 meters of DNA. This long DNA strand is packed inside a nucleus measuring only 10-20 microns in diameter with the help of specialized DNA-binding proteins called histones. Together they form a compact DNA-protein complex called chromatin. The chromatin is further compacted into higher-order structures. The highest level of compaction is achieved during...
19.4K
Chromatin Packaging02:21

Chromatin Packaging

9.8K
9.8K
Spreading of Chromatin Modifications02:25

Spreading of Chromatin Modifications

9.5K
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer...
9.5K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.6K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.6K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.9K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chromatin dynamics and cellular energy homeostasis.

Journal of biochemistry·2026
Same author

Context-dependent interplay of Swi-Snf and Tup1-Cyc8 influences chromatin and transcription at antagonistically regulated genes.

Nature communications·2026
Same author

Author Correction: The SESAME complex regulates cell senescence through the generation of acetyl-CoA.

Nature metabolism·2026
Same author

Integrative Structural Modeling of Intrinsically Disordered Regions in a Human HDAC2 Chromatin Remodeling Complex.

bioRxiv : the preprint server for biology·2026
Same author

Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome.

bioRxiv : the preprint server for biology·2026
Same author

Altered transposon element-derived genes distort oxygen-free radical scavenger systems in FXD.

NAR molecular medicine·2026
Same journal

Lactate as a Chemical Modification on Proteins and Metabolites.

Annual review of biochemistry·2026
Same journal

Nucleocytoplasmic Transport.

Annual review of biochemistry·2026
Same journal

Packaging of Single-Stranded RNA in Viruses and Virus-Like Particles.

Annual review of biochemistry·2026
Same journal

Shaping of the Infant Gut Microbiome by Milk Oligosaccharides.

Annual review of biochemistry·2026
Same journal

Proteostasis Deregulation by Metabolism Drives the Hallmarks of Cancer.

Annual review of biochemistry·2026
Same journal

JoAnne Stubbe's Radical Path: A Story of Passion, Curiosity, and Persistence.

Annual review of biochemistry·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Chromatin Extraction from Frozen Chimeric Liver Tissue for Chromatin Immunoprecipitation Analysis
09:26

Chromatin Extraction from Frozen Chimeric Liver Tissue for Chromatin Immunoprecipitation Analysis

Published on: March 23, 2021

3.2K

Chromatin and Metabolism.

Tamaki Suganuma1, Jerry L Workman1

  • 1Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA; email: tas@stowers.org , jlw@stowers.org.

Annual Review of Biochemistry
|June 22, 2018
PubMed
Summary
This summary is machine-generated.

Cellular metabolism fuels chromatin functions, influencing gene expression and epigenetics. Imbalances between metabolism and chromatin activity can lead to metabolic diseases and altered lifespan.

Keywords:
chromatincofactorsenergy homeostasishistone modificationsmetabolismmetabolites

More Related Videos

Sequential Salt Extractions for the Analysis of Bulk Chromatin Binding Properties of Chromatin Modifying Complexes
07:41

Sequential Salt Extractions for the Analysis of Bulk Chromatin Binding Properties of Chromatin Modifying Complexes

Published on: October 2, 2017

8.9K
Metabolic Profile Analysis of Zebrafish Embryos
05:41

Metabolic Profile Analysis of Zebrafish Embryos

Published on: January 14, 2013

20.5K

Related Experiment Videos

Last Updated: Feb 8, 2026

Chromatin Extraction from Frozen Chimeric Liver Tissue for Chromatin Immunoprecipitation Analysis
09:26

Chromatin Extraction from Frozen Chimeric Liver Tissue for Chromatin Immunoprecipitation Analysis

Published on: March 23, 2021

3.2K
Sequential Salt Extractions for the Analysis of Bulk Chromatin Binding Properties of Chromatin Modifying Complexes
07:41

Sequential Salt Extractions for the Analysis of Bulk Chromatin Binding Properties of Chromatin Modifying Complexes

Published on: October 2, 2017

8.9K
Metabolic Profile Analysis of Zebrafish Embryos
05:41

Metabolic Profile Analysis of Zebrafish Embryos

Published on: January 14, 2013

20.5K

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Epigenetics

Background:

  • Chromatin, the complex of DNA and proteins, is a significant consumer of cellular energy derived from metabolic processes.
  • Metabolic status is intricately linked with transcription and translation, forming a feedback loop that regulates metabolism.
  • Energy conservation by chromatin processes can be crucial for cell survival.

Purpose of the Study:

  • To review the synthesis of metabolites essential for chromatin function.
  • To elucidate the intricate relationships between cellular metabolism and chromatin dynamics.
  • To discuss the feedback mechanisms by which chromatin influences metabolic regulation.

Main Methods:

  • Literature review focusing on the interplay between metabolism and chromatin.
  • Analysis of metabolite synthesis pathways relevant to chromatin modification.
  • Examination of how cellular metabolic state impacts epigenetic modifications and nucleosome organization.

Main Results:

  • Metabolites serve as essential cofactors and coenzymes for chromatin modification reactions.
  • Cellular metabolic status directly influences posttranslational histone modifications and nucleosome structure.
  • Transcription, translation, and nucleic acid biogenesis dynamically adapt to cellular metabolism.

Conclusions:

  • Disruptions in metabolic enzymes or imbalances between metabolism and chromatin activity are implicated in metabolic diseases and lifespan regulation.
  • Understanding the bidirectional communication between metabolism and chromatin is vital for comprehending cellular homeostasis.
  • This review highlights the critical role of metabolic regulation in epigenetic processes and vice versa.