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Quantification of Atherosclerosis in Mice
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[Cerebral atherosclerosis: a biomarker profile].

M M Tanashyan1, O V Lagoda1, A N Evdokimenko1

  • 1Research Center of Neurology, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|June 22, 2018
PubMed
Summary

Biomarker profiles in brachiocephalic artery atherosclerosis patients reveal distinct patterns in symptomatic versus asymptomatic individuals. This research aids in predicting stroke risk and preventing cardiovascular events.

Keywords:
biomarkerscerebral atherosclerosiscerebrovascular pathologystroke

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Area of Science:

  • Cardiovascular Research
  • Biomarker Discovery
  • Neuroscience

Background:

  • Atherosclerosis of brachiocephalic arteries is a significant risk factor for stroke.
  • Identifying reliable biomarkers is crucial for assessing disease progression and patient prognosis.
  • Current diagnostic methods may benefit from integrative biomarker profiles for improved accuracy.

Purpose of the Study:

  • To evaluate changes in specific biomarkers in patients with brachiocephalic artery atherosclerosis.
  • To establish a comprehensive biomarker profile for cerebral atherosclerosis.
  • To develop an integrative index for assessing atherosclerosis burden and predicting ischemic complications.

Main Methods:

  • Inclusion of 124 patients with internal carotid artery atherosclerotic lesions, stratified by stroke history.
  • Utilized ultrasound, neuroimaging, and analysis of biomarkers related to atherogenesis stages.
  • Examined pathomorphological parameters of atherosclerotic plaques from carotid endarterectomy specimens.

Main Results:

  • Significant differences in plasma nitric oxide (NO) metabolites (NO2, NO3, NO) between symptomatic and asymptomatic groups.
  • Elevated lipoprotein-associated phospholipase A2 confirmed a pro-inflammatory state in stroke patients.
  • Decreased adiponectin and altered fibrinolytic activity markers (plasminogen activator, plasminogen activator inhibitor-1) indicated prothrombotic changes in symptomatic patients.

Conclusions:

  • Biomarker identification enhances the accuracy of prognosis and prevention of sudden cardiovascular death.
  • A novel scale of biomarker 'burden' for cerebral atherosclerosis was developed.
  • This approach represents a step towards individualized prevention of ischemic complications.