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Updated: Feb 8, 2026
08:03
Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
Published on: December 1, 2016
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Recent advances in nanoparticle carriers for photodynamic therapy
Gawon Yi1, Suk Ho Hong2, Jihwan Son1
1Department of Medical Lifescience, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Quantitative Imaging in Medicine and Surgery
|June 22, 2018
Summary
Recent advances in nanoparticle (NP) development enhance photodynamic therapy (PDT) efficiency. Nanoparticle carriers improve photosensitizer delivery and stability for targeted disease treatment.
Area of Science:
- Biomedical Engineering
- Materials Science
- Oncology
Background:
- Photodynamic therapy (PDT) requires efficient delivery of photosensitizers (PSs) to target sites.
- Nanoparticles (NPs) offer a promising platform for drug delivery and medical imaging.
- Nanomedicine approaches are crucial for overcoming challenges in PDT efficacy.
Purpose of the Study:
- To review recent advancements in NP-based strategies for enhanced photodynamic therapy.
- To explore the application of organic and inorganic NPs as carriers for photosensitizers.
- To highlight novel PDT techniques and the role of NPs in their development.
Main Methods:
- Literature search of the PubMed database using keywords: NP, nanomedicine, PDT, photosensitizer (PSs), and drug delivery.
- Analysis of studies focusing on NP carriers for PSs in PDT applications.
- Review of emerging PDT techniques like aggregation-induced emission (AIE) and luminescence-based PDT.
Main Results:
- NP carriers significantly improve the water solubility and stability of PSs for in vivo administration.
- NP delivery systems enhance PS circulation time and accumulation at target disease sites.
- Various NP formulations, based on organic and inorganic materials, have demonstrated efficacy in PDT.
Conclusions:
- Nanoparticles are pivotal in advancing photodynamic therapy by improving photosensitizer delivery and therapeutic outcomes.
- Nanomedicine strategies utilizing NPs are essential for developing more effective and targeted PDT treatments.
- This review provides valuable insights for researchers developing or applying NPs in efficient PDT.
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