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Episodic and working memory function in Primary Progressive Aphasia: A meta-analysis.
Willem S Eikelboom1, Nikki Janssen2, Lize C Jiskoot3
1Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands.
Neuroscience and Biobehavioral Reviews
|June 22, 2018
Summary
Distinguishing between Primary Progressive Aphasia (PPA) variants like logopenic (lv-PPA) and non-fluent (nfv-PPA) is difficult. This meta-analysis shows memory tests can help differentiate these PPA types, with lv-PPA exhibiting more pronounced memory deficits.
Area of Science:
- Neurology
- Cognitive Neuroscience
Background:
- Primary Progressive Aphasia (PPA) comprises several variants, posing diagnostic challenges for clinicians.
- Differentiating non-fluent (nfv-PPA) and logopenic (lv-PPA) variants is particularly difficult.
- Prior research indicates memory function may serve as a distinguishing factor between PPA subtypes.
Purpose of the Study:
- To conduct a meta-analysis comparing memory function across different PPA variants.
- To evaluate the utility of memory tests in differentiating between PPA subtypes, specifically nfv-PPA and lv-PPA.
Main Methods:
- A systematic meta-analysis was performed, extracting effect sizes from 41 studies involving 849 participants.
- Random-effects models were employed to compare episodic and working memory performance.
- Comparisons included PPA patients versus healthy controls and among the distinct PPA variants (lv-PPA, nfv-PPA, sv-PPA).
Main Results:
- Significant memory deficits were observed in all PPA variants compared to controls.
- Logopenic variant PPA (lv-PPA) demonstrated the largest effect size for memory deficits (Hedges' g = -2.04).
- Semantic variant PPA (sv-PPA) primarily showed verbal memory impairments, while lv-PPA exhibited poorer performance on both verbal and non-verbal memory tests compared to nfv-PPA.
Conclusions:
- Memory deficits are more severe in lv-PPA than in nfv-PPA.
- Memory testing can be a valuable tool for clinicians in distinguishing between lv-PPA and nfv-PPA.
- These findings underscore the importance of detailed memory assessments in the diagnosis of PPA variants.
Keywords:
Frontotemporal dementiaLogopenic aphasiaMemoryMeta-analysisPrimary progressive aphasiaProgressive nonfluent aphasiaSemantic dementiaSystematic reviewMore Related Videos
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