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Related Concept Videos

Applications of Integration to Find Hydrostatic Pressure01:30

Applications of Integration to Find Hydrostatic Pressure

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Hydrostatic force is a fluid's total force at rest on a surface. For a horizontal surface submerged at a fixed depth, the pressure is constant and calculated as the product of fluid density, gravitational acceleration, and depth. In the case of a vertical dam wall submerged in water, this force is not evenly distributed due to the increasing pressure with depth. This variation arises from the cumulative weight of the water above each point. Integration is used to account for the continuous...
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Hydrostatic Pressure Force on a Plane Surface01:04

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When a plane surface is submerged in a fluid, hydrostatic forces develop on the surface due to the fluid's pressure. For horizontal surfaces, the pressure exerted by the fluid is uniform because the depth remains constant. The resultant force is determined by the pressure at the given depth multiplied by the area of the surface, and it acts through the centroid of the surface. For vertical surfaces, the pressure varies with depth, increasing as the distance from the fluid's free surface...
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Hydrostatic Pressure Force on a Curved Surface01:04

Hydrostatic Pressure Force on a Curved Surface

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Hydrostatic pressure on curved surfaces is a fundamental concept in fluid mechanics with broad applications in the civil engineering field. When fluid is in contact with a curved surface, as in a reservoir, dam, or storage tank, it exerts pressure that varies in magnitude and direction along the curved surface. To assess the total hydrostatic force exerted by the fluid on a curved structure, engineers typically isolate the fluid volume adjacent to the surface and analyze the forces acting on...
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Passive Filters01:27

Passive Filters

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Passive filters are utilized to shape the frequency spectrum of signals across a diverse array of applications. These filters, using only passive elements like resistors (R), inductors (L), and capacitors (C), are capable of selectively allowing or blocking certain frequency ranges without the need for external power sources.
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Vapor Pressure02:34

Vapor Pressure

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When a liquid vaporizes in a closed container, gas molecules cannot escape. As these gas phase molecules move randomly about, they will occasionally collide with the surface of the condensed phase, and in some cases, these collisions will result in the molecules re-entering the condensed phase. The change from the gas phase to the liquid is called condensation. When the rate of condensation becomes equal to the rate of vaporization, neither the amount of the liquid nor the amount of the vapor...
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Active versus Passive Immunity01:31

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Immunity, along with the ability to limit pathogen growth to prevent significant body tissue damage, can be gained either by (1) actively developing an immune response within the individual after exposure to a pathogen or after getting vaccinated or (2) passively transferring immune components from an immune individual to one who is nonimmune. Both these forms of immunity can be found naturally and in medical practices.
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A hydrostatic pressure-driven passive micropump enhanced with siphon-based autofill function.

Xiaolin Wang1, Da Zhao, Duc T T Phan

  • 1Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China.

Lab on a Chip
|June 23, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces an enhanced passive micropump for continuous, steady fluid flow in microfluidics. The siphon-based autofill function enables autonomous, long-term perfusion without external power, ideal for cell applications and point-of-care testing.

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Area of Science:

  • Microfluidics
  • Biomedical Engineering
  • Biotechnology

Background:

  • Micropumps are crucial for microfluidic applications like cell culture and point-of-care testing (POCT).
  • Existing hydrostatic pressure-driven passive micropumps lack sustained steady flow.
  • Need for autonomous, self-powered, and long-term perfusion systems.

Purpose of the Study:

  • To develop an autonomous, self-powered micropump with continuous, steady flow.
  • To enhance passive micropump performance using a siphon-based autofill mechanism.
  • To enable flexible, multiplexed medium delivery for microfluidic systems.

Main Methods:

  • Design and fabrication of a hydrostatic pressure-driven passive micropump with a siphon-based autofill function.
  • Characterization of refilling time based on cycle number and siphon diameter.
  • Validation using an in vitro vasculogenesis model over several days.

Main Results:

  • The enhanced micropump achieves autonomous and continuous perfusion with steady flow.
  • Refilling time is influenced by the number of cycles and siphon diameter.
  • Demonstrated multiplexed medium delivery with high flexibility.
  • Sustained steady medium perfusion for up to 5 days without medium changes.

Conclusions:

  • The proposed micropump offers a power-free, autonomous solution for long-term microfluidic perfusion.
  • It provides a flexible platform for various microfluidic applications, including cell-based assays and POCT.
  • This technology is poised to become a key component in advanced microfluidic systems.