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Published on: November 6, 2018
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Renal Replacement Therapy in Severe Burns: A Multicenter Observational Study
Kevin K Chung1,2, Elsa C Coates3, William L Hickerson4
1Brooke Army Medical Center, Fort Sam Houston, Texas.
Summary
Severe burn patients requiring renal replacement therapy (RRT) have a 50% in-hospital mortality rate. However, most survivors eventually recover kidney function, indicating RRT
Area of Science:
- Nephrology
- Burn Critical Care
- Renal Replacement Therapy
Background:
- Acute kidney injury (AKI) in severe burn patients historically carries high mortality.
- Renal replacement therapy (RRT) has been utilized for decades in this patient population.
- Limited multicenter data exists on burn patients undergoing RRT.
Purpose of the Study:
- To evaluate demographic, treatment, and outcomes data for severe burn patients treated with RRT.
- To provide a comprehensive overview of RRT use in a multicenter burn cohort.
Main Methods:
- Multicenter observational study including 170 adult severe burn patients requiring RRT.
- Data collected on demographics, burn characteristics, RRT mode, and outcomes.
- Continuous venovenous hemofiltration was the preferred RRT modality.
Main Results:
- Mean age 51 years, 38% total body surface area burn, 27 Injury Severity Score.
- 50% in-hospital mortality rate.
- Among survivors, 21% needed RRT at discharge, 9% at 6 months post-discharge.
Conclusions:
- This is the first multicenter cohort study of burn patients undergoing RRT.
- Mortality is comparable to other critically ill populations requiring RRT.
- Most surviving patients achieve renal function recovery.
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