Related Experiment Video

Updated: Feb 8, 2026

Author Spotlight: Insights into the Techniques and Findings of Recent Advancements in Epilepsy Research
04:41

Author Spotlight: Insights into the Techniques and Findings of Recent Advancements in Epilepsy Research

Published on: October 13, 2023

2.3K

[The expression of calcium sensing receptor(CaSR) and MAPK pathway changes in myocardial cells of epilepsy rats]

Jin Guo1, Yang Liu1,2, Chao Wang3

  • 1The Affiliated the Third Hospital, Jiamusi 154002.

Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology
|June 23, 2018
PubMed
Abstract

Insights

Epilepsy in rats increases calcium-sensing receptor (CaSR) and MAPK pathway activation in heart cells, leading to cardiac dysfunction. CaSR modulation impacts myocyte apoptosis.

Area of Science:

  • Cardiology
  • Neurology
  • Molecular Biology

Background:

  • Epilepsy is associated with cardiac complications.
  • The role of calcium-sensing receptor (CaSR) and mitogen-activated protein kinase (MAPK) pathways in epilepsy-induced cardiac changes is not fully understood.

Purpose of the Study:

  • To investigate myocardial cell alterations in a chronic epileptic rat model.
  • To examine the expression of CaSR and MAPK pathway components in the hearts of these rats.

Main Methods:

  • A chronic epileptic rat model was established using pentylenetetrazole (PTZ).
  • Interventions included CaSR agonist (spermine) and inhibitor (Chalhex231).
  • Cardiac function, myocardial tissue morphology, and protein expression (CaSR, ERK, p-ERK, p-JNK) were assessed.

Main Results:

  • PTZ-treated rats showed elevated cardiac enzymes (CK, CK-MB) and impaired cardiac function.
  • Myocardial ultrastructure revealed significant injury.
  • Increased CaSR and p-JNK, with decreased p-ERK expression were observed in epilepsy models.
  • Spermine exacerbated these changes, while Chalhex231 reversed them.

Conclusions:

  • Chronic epilepsy in rats is linked to increased CaSR expression in myocardial cells.
  • CaSR activation influences MAPK pathway signaling, contributing to cardiac myocyte apoptosis.
Keywords:
calcium-sensing receptorepilepsymitogen-activated proteinkinasemyocardial cells

More Related Videos

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System08:54

Imaging Spatial Reorganization of a MAPK Signaling Pathway Using the Tobacco Transient Expression System

Published on: March 20, 2016

10.3K
Temporal Quantification of MAPK Induced Expression in Single Yeast Cells07:59

Temporal Quantification of MAPK Induced Expression in Single Yeast Cells

Published on: October 4, 2013

8.9K

Related Concept Videos

Insulin: The Receptor and Signaling Pathways01:28

Insulin: The Receptor and Signaling Pathways

Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
3.4K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
8.5K
The Sense of Self: Reflected Self-Appraisal and Social Comparison02:57

The Sense of Self: Reflected Self-Appraisal and Social Comparison

According to Charles Cooley, we base our image on what we think other people see (Cooley 1902). We imagine how we must appear to others, then react to this speculation. We don certain clothes, prepare our hair in a particular manner, wear makeup, use cologne, and the like—all with the notion that our presentation of ourselves is going to affect how others perceive us. We expect a certain reaction, and, if lucky, we get the one we desire and feel good about it. But more than that, Cooley...
56.1K
Internal Receptors01:31

Internal Receptors

Many cellular signals are hydrophilic and therefore cannot pass through the plasma membrane. However, small or hydrophobic signaling molecules can cross the hydrophobic core of the plasma membrane and bind to internal, or intracellular, receptors that reside within the cell. Many mammalian steroid hormones use this mechanism of cell signaling, as does nitric oxide (NO) gas.
74.7K
Enzyme-linked Receptors01:00

Enzyme-linked Receptors

Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
86.7K
Types of Receptors: Cell Surface Receptors01:28

Types of Receptors: Cell Surface Receptors

Cell-surface receptors, also known as transmembrane receptors, are cell surface, membrane-anchored (integral) proteins that bind to external ligand molecules. This type of receptor spans the plasma membrane and performs signal transduction, converting an extracellular signal into an intracellular signal. Ligands that interact with cell-surface receptors do not have to enter the cell that they affect. Cell-surface receptors are also called cell-specific proteins or markers because they are...
27.5K