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[The relationship between acute inflammatory cytokines, nerve function defect, daily living ability and PSD]
Ping Li1, Qiao-Lian Zhang1, Shuang-Ying Li1
1Department of Neurology, Affiliated Hospital of Logistics University of PAP, Tianjin 300162, China.
Summary
Poststroke depression (PSD) is linked to inflammatory cytokines and functional impairment. Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and Barthel index are key risk factors in the acute phase.
Area of Science:
- Neurology
- Psychiatry
- Immunology
Background:
- Poststroke depression (PSD) is a common complication following acute cerebral infarction.
- Understanding the factors contributing to PSD is crucial for effective management and improved patient outcomes.
Purpose of the Study:
- To investigate the correlation between poststroke depression (PSD) and serum inflammatory cytokines, neurologic impairment, and daily living abilities in patients with acute cerebral infarction.
- To identify independent risk factors for PSD at different time points after stroke.
Main Methods:
- A cohort of 280 patients with acute cerebral infarction were assessed for PSD using the Hamilton Depression Rating Scale (HDRS) at admission and 3 months post-stroke.
- Serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) were measured.
- Neurologic impairment and daily living abilities were evaluated using the NIH Stroke Scale (NIHSS) and Barthel Index, respectively. Logistic regression analysis was employed to determine risk factors.
Main Results:
- Serum inflammatory cytokines (TNF-α, IL-6) were elevated in the PSD group compared to the non-PSD group at admission.
- Patients with PSD exhibited significant differences in NIHSS scores and Barthel Index compared to non-PSD patients during both acute and recovery stages.
- Tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and Barthel Index were identified as independent risk factors for PSD in the acute phase. NIHSS score and Barthel Index were significant in the recovery period.
Conclusions:
- The underlying mechanisms of PSD vary depending on the stroke phase.
- Inflammatory markers (TNF-α, IL-6) and functional status (Barthel Index) are significant predictors of PSD in the acute phase.
- Neurologic impairment (NIHSS) and functional status (Barthel Index) are critical factors in the recovery phase of PSD.
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