Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

Shu-Shan Gao1, Nathchar Naowarojna2, Ronghai Cheng2

  • 1State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Related Concept Videos

Enzymes02:34

Enzymes

Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
95.0K
Enzyme Kinetics01:19

Enzyme Kinetics

Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
104.2K
Newton's Third Law: Examples01:08

Newton's Third Law: Examples

Newton's third law states that every action has an equal and opposite reaction. Consider a swimmer pushing off the side of a pool. They push against the wall of the pool with their feet and accelerate in the direction opposite to that of their push. This occurs because the wall exerts an equal and opposite force on the swimmer. Here, the forces do not cancel out each other as they are acting on different systems. In this case, there are two systems: the swimmer and the wall. If we select...
27.2K
Free Body Diagrams: Examples01:07

Free Body Diagrams: Examples

Solving problems that involve forces is easy using free-body diagrams. A free-body diagram is a sketch showing all the external forces that are acting on an object or system. The object or system is represented by a single isolated point (or free body). Only those forces acting on it that originate outside of the object or system—the external forces—are shown. The forces are represented by vectors extending outward from the free body. Imagine a person sitting on a chair. Here, the...
14.7K
The Wave Nature of Light02:12

The Wave Nature of Light

The nature of light has been a subject of inquiry since antiquity. In the seventeenth century, Isaac Newton performed experiments with lenses and prisms and was able to demonstrate that white light consists of the individual colors of the rainbow combined together. Newton explained his optics findings in terms of a "corpuscular" view of light, in which light was composed of streams of extremely tiny particles traveling at high speeds according to Newton's laws of motion.
61.5K
Frequency-dependent Selection01:21

Frequency-dependent Selection

When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
24.2K