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[Circadian Regulation and Its Disorders in Parkinson's Disease Patients. Part 2. Experimental Models, Alpha-Synuclein
Abstract:
Circadian disturbances-related to Parkinson's disease are reviewed and possible pathogenetic mechanisms are discussed. The role of dopaminergic system degeneration in development of circadian disfunction is stressed. As to possible mechanism of circadian disfunction not related to dopamine deficiency, the accumulation of alpha-synuclein in the suprachiasmatic nucleus is regarded. The data on dopamine and melatonin levels disbalance in Parkinson's disease patients and its role in disturbances of circadian rhythms of physiological processes are analyzed.
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