[Lipid Peroxidation and Antioxidant Defense System in Humans after Hypergravitational Influence of Different Force.]

In the group of 14 volunteers in age from 25 to 45 years the effects +Gz (head-pelvis) overloads, amount to 3, 5 and 7 g with a rising rate of 0.03 g/s, intensity of lipid peroxidation (LPO) and the state of the system of antioxidant protection (AOP) had been studied. In the blood the content of LPO products - diene conjugates, malon dialdehyde, shiff bases and the condition of water-phase(activity of catalase, glutathione peroxidase) and lipid-phase (content of tocopherol) based components of the AOP system determined. It is found that hypergravitational influence of the size of 3 g was accompanied by signs of a slight LPO activation with its subsequent inhibition; when the value of the overload was observed in 5 g only signs of LPO inhibition took place; in case of overload force in 7 g was not observed statistically significant changes in all studied parameters. The most likely explanation of the observed phenomenon may be the activation of a passive protection mechanisms of the biomembrane, providing change its phase state. Further investigation of the mechanisms of compensation and control the intensity of free radical processes in hypergranulation influence is necessary.