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Dynamic Morphologies and Stability of Droplet Interface Bilayers.

Benjamin Guiselin1, Jack O Law1, Buddhapriya Chakrabarti2

  • 1Department of Physics, Durham University, Durham DH1 3LE, United Kingdom.

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|June 23, 2018
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Summary

We developed a model for droplet interface bilayers (DIBs) stability. Lipid kinetics and evaporation determine DIB growth or detachment, with a critical size impacting miniaturization.

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Area of Science:

  • Soft Matter Physics
  • Physical Chemistry
  • Biophysics

Background:

  • Droplet interface bilayers (DIBs) are model systems for studying lipid behavior.
  • Understanding DIB stability is crucial for their application in various fields.
  • Factors influencing DIB morphology, such as lipid kinetics and evaporation, require theoretical investigation.

Purpose of the Study:

  • To develop a theoretical framework for DIB dynamic morphologies and stability.
  • To account for lipid kinetics and droplet evaporation in DIBs.
  • To quantitatively describe pathways of DIB instability.

Main Methods:

  • Theoretical modeling of DIBs.
  • Inclusion of lipid kinetics in monolayers and bilayer.
  • Consideration of droplet evaporation due to osmotic and Laplace pressure imbalance.

Main Results:

  • The model quantitatively describes DIB instability pathways.
  • Slow lipid desorption leads to bilayer growth and hemispherical droplet shapes.
  • Fast lipid desorption causes bilayer shrinkage and droplet detachment.
  • A critical DIB size for instability was identified.

Conclusions:

  • The theoretical framework explains observed DIB dynamic behaviors.
  • Lipid desorption timescale relative to evaporation dictates DIB fate.
  • The critical size may explain challenges in DIB platform miniaturization.