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Alkaloids from Melodinus henryi with anti-inflammatory activity
Jin-Qian Yu1, Xiao-Wei Sun2, Zhi-Wei Wang1
1a Shandong Key Laboratory of TCM Quality Control Technology, Shandong Analysis and Test Center , Qilu University of Technology (Shandong Academy of Sciences) , Jinan 250014 , China.
Abstract:
One new quinolinic scandine-type monoterpeniod alkaloid, 3-oxo-scandine (1), as well as seven known ones (2-8), was isolated from the roots of Melodinus henryi. Their structures were elucidated by extensive spectroscopic analysis. All of the compounds were prepared and evaluated for their anti-inflammatory activities by measuring the inhibitory activity of nitric oxide (NO) in vitro in RAW 264.7 mouse peritoneal macrophages. Compounds 6 and 7 showed significant activities with IC50 values of 8.54 and 5.19 μM, respectively.
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