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Related Experiment Video

Updated: Feb 8, 2026

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Author Spotlight: Enhancing Diagnostic Strategies and Biomarker Development for Comprehensive Lung Function Analysis

Published on: August 9, 2024

Pulmonary pericytes regulate lung morphogenesis.

Katsuhiro Kato¹, Rodrigo Diéguez-Hurtado², Do Young Park^3,4

¹Department of Tissue Morphogenesis, Max Planck Institute for Molecular Biomedicine, and University of Münster, Faculty of Medicine, D-48149, Münster, Germany. katsuhiro.kato@mpi-muenster.mpg.de.

Nature Communications

|June 24, 2018

Summary

This summary is machine-generated.

Pericytes regulate lung development by signaling to epithelial and endothelial cells. Loss of YAP and TAZ in pericytes impairs lung alveologenesis through reduced growth factor signaling.

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Area of Science:

Vascular biology
Developmental biology
Cell signaling

Background:

Blood vessels are crucial for circulation and organ development, with endothelial cells releasing paracrine signals.
Pericytes are mesenchymal cells associated with blood vessels, maintaining vessel integrity.
The Hippo pathway, involving YAP and TAZ, is a key regulator of organ growth.

Purpose of the Study:

To investigate the role of pericytes in postnatal lung morphogenesis.
To determine the function of Hippo pathway components YAP and TAZ in lung pericytes.

Main Methods:

Utilized a mouse model lacking YAP and TAZ expression specifically in pericytes.
Assessed lung alveologenesis and measured expression of key signaling molecules like hepatocyte growth factor and angiopoietin-1.
Examined the activation of the c-Met receptor in alveolar epithelial cells.

Main Results:

Pericyte-specific deletion of YAP and TAZ led to defective lung alveologenesis.
Mutant pericytes showed significantly reduced hepatocyte growth factor expression.
YAP and TAZ were essential for angiopoietin-1 expression in pulmonary pericytes, which autocrinely regulates hepatocyte growth factor.

Conclusions:

Pericytes act as critical regulators of epithelial and endothelial morphogenesis in the postnatal lung.
Pericyte-derived YAP and TAZ control lung development by orchestrating signaling pathways involving hepatocyte growth factor and angiopoietin-1.
These findings highlight organ-specific signaling properties of pericytes in coordinating tissue development.