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Histones and heart failure in diabetes
Veera Ganesh Yerra1, Andrew Advani2
1Keenan Research Centre for Biomedical Science and Li Ka Shing Knowledge Institute of St. Michael's Hospital, 6-151, 61 Queen Street East, Toronto, ON, M5C 2T2, Canada.
Cellular and Molecular Life Sciences : CMLS
|June 24, 2018
Summary
Histone modifications are implicated in diabetic heart failure. Understanding these epigenetic changes and their regulators may offer new therapeutic strategies for managing this major diabetes complication.
Area of Science:
- Cardiovascular Science
- Epigenetics
- Metabolic Disease Research
Background:
- Heart failure is a significant long-term complication of diabetes.
- Advances in understanding diabetes complications often stem from studying microvascular and macrovascular diseases, including epigenetics and histone modifications.
Purpose of the Study:
- To review principal histone modifications and their enzymes in heart failure and diabetic hearts.
- To discuss the roles of histone modifications in heart failure and diabetic conditions.
- To explore potential therapeutic manipulation of histone modifications for diabetic heart failure.
Main Methods:
- Literature review of studies on histone modifications in heart failure and diabetes.
- Analysis of enzymatic writers and erasers of histone modifications.
- Drawing parallels from research on microvascular and macrovascular diabetes complications.
Main Results:
- Histone modifications are present and perturbed in human heart failure and diabetic hearts.
- Specific histone modifications and their associated enzymes play roles in cardiac pathology.
- Lessons from other diabetes complications inform the understanding of cardiac involvement.
Conclusions:
- Histone modifications are relevant to the pathobiology of diabetic heart failure.
- Targeting histone modification pathways presents a potential therapeutic avenue.
- Further research into epigenetic mechanisms could alter the course of heart failure in diabetes.
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