Phthalide dimers from Angelica sinensis and their COX-2 inhibition activity
Jie-Li Lv1, Lai-Bin Zhang1, Li-Min Guo1
1School of Pharmacy, Xinxiang Medical University, Xinxiang 453003, PR China.
Abstract:
Four new dimeric phthalides, angesinenolides C-F (1-4), along with three known ones, were isolated from the roots of Angelica sinensis. Their structures were determined by means of HRMS and NMR experiments. The structures of compounds 1 and 3 were confirmed using X-ray crystallographic data. All isolated compounds were tested for activities on the inhibition of COX-2 enzyme in vitro. Compounds 1-6 exhibited inhibitory activity against COX-2 with IC50 values ranging from 29.32 ± 0.07 to 137.91 ± 0.24 μM.
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