Patient Selection for Cytoreductive Surgery.

Area of Science:

• Oncology
• Surgical Oncology
• Gastroenterology

Background:

• Peritoneal malignancies present a wide range of aggressiveness, from indolent appendiceal adenocarcinoma to invasive signet ring cell types.
• These cancers can originate from the appendix, colon, and stomach, impacting the peritoneum.

Purpose of the Study:

• To discuss the appropriate evaluation and patient selection for cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC).
• To highlight the importance of understanding disease biology, distribution, and volume for treatment decisions.

Main Methods:

• Review of current understanding of peritoneal surface malignancies.
• Discussion of diagnostic evaluation strategies.
• Criteria for patient selection for cytoreductive surgery and HIPEC.

Main Results:

• The spectrum of peritoneal malignancies necessitates tailored treatment approaches.
• Accurate assessment of disease characteristics is vital for successful outcomes.

Conclusions:

• Cytoreduction and HIPEC are critical for long-term survival in selected patients with peritoneal surface malignancies.
• Comprehensive patient evaluation is essential for optimizing treatment selection and improving survival rates.