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Related Experiment Videos

Psychological functioning in Parkinson's disease post-deep brain stimulation: Self-regulation and executive

Hannah L Combs1, Natasha E Garcia-Willingham2, David T R Berry2

  • 1Department of Psychology, University of Kentucky, Lexington, KY, United States; Department of Neurology, Baylor College of Medicine, Houston, TX, United States.

Journal of Psychosomatic Research
|June 25, 2018
PubMed
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Parkinson's disease patients often have self-regulation and executive functioning deficits, with impulse control disorders being most common. These extra-motor impairments significantly impact daily life.

Area of Science:

  • Neuroscience
  • Neurology
  • Psychology

Background:

  • Parkinson's disease (PD) is a neurodegenerative disorder affecting the basal ganglia, causing motor and non-motor symptoms.
  • Non-motor deficits in PD may stem from self-regulation (SR) and executive functioning (EF) impairments.
  • Further investigation into the prevalence and scope of SR and EF deficits in PD is warranted.

Purpose of the Study:

  • To examine the prevalence and range of self-regulation (SR) and executive functioning (EF) impairments in Parkinson's disease (PD) patients.
  • To explore the relationship between SR, EF, and heart rate variability (HRV) in PD patients post-deep brain stimulation (DBS).

Main Methods:

  • A sample of 31 PD patients undergoing DBS surgery completed neurocognitive tests, HRV assessments, and self-report questionnaires.
Keywords:
Deep brain stimulationExecutive functioningHeart rate variabilityImpulse control disorderParkinson's diseaseSelf-regulation

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  • Measures assessed impulse control disorder (ICD) symptoms, depressive symptoms, verbal fluency, mental flexibility, metacognition, and behavioral regulation.
  • Correlations between SR, EF, and HRV were analyzed.

    • Main Results:

    • High prevalence of impairments observed for ICD symptoms (74%), depressive symptoms (48%), verbal fluency (39%/36%), mental flexibility (32%), and self-reported SR (32%/29%).
    • Modest and variable correlations between SR and EF constructs challenged the notion of SR as a unitary construct.
    • Higher resting HRV was inconsistently linked to better EF and not significantly associated with self-reported SR.

    Conclusions:

    • PD patients exhibit diverse extra-motor deficits, including significant SR and EF impairments.
    • Healthcare professionals should be aware of these deficits, especially ICDs, and their impact on patients' daily functioning.
    • The findings suggest SR is a multifaceted construct, not solely reliant on a common resource, in PD patients post-DBS.