Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hierarchy of Motor Control01:18

Hierarchy of Motor Control

6.3K
The hierarchy of motor control refers to the different levels of organization and processing involved in controlling movement in the body. These levels range from higher cortical areas involved in planning and decision-making to lower spinal cord reflexes that respond automatically to external stimuli.
6.3K
Maslow's Need Hierarchy Theory01:27

Maslow's Need Hierarchy Theory

1.1K
Abraham Maslow's theory of motivation, introduced in 1943, is widely known as the "Hierarchy of Needs." This theory posits that human needs are arranged in a hierarchical structure, starting with basic survival needs and progressing toward more complex psychological and self-fulfillment desires. The hierarchy is typically a pyramid, and the lower needs must be satisfied to reach the next level.
At the pyramid's base are physiological needs, including food, water, and shelter...
1.1K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.9K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.9K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

4.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
4.1K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

3.9K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.9K
Taxonomy01:31

Taxonomy

89.5K
Taxonomy is the science of defining and naming groups of biological organisms based on shared characteristics. It uses a hierarchy of increasingly inclusive categories with Latin names. The smallest units of taxonomy, species and genus, are used to assign a formal, taxonomic name to each species in a system. This classification system, referred to as binomial nomenclature, was formalized by Carolus Linnaeus in the 18th century.
Hierarchy of Taxonomy
The hierarchy that Carolus Linnaeus first...
89.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Medicaid coverage of tobacco-dependence treatments on smoking cessation.

International journal of environmental research and public health·2010
Same author

Cytokine and autoantibody patterns in acute liver failure.

Journal of immunotoxicology·2009
Same author

A novel scoring system for prognostic prediction in d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure BALB/c mice.

BMC gastroenterology·2009
Same author

Mammalian target of rapamycin signaling pathway contributes to glioma progression and patients' prognosis.

The Journal of surgical research·2009
Same author

Estrogen receptor neurobiology and its potential for translation into broad spectrum therapeutics for CNS disorders.

Current molecular pharmacology·2009
Same author

Transcriptional and post-translational regulation of adiponectin.

The Biochemical journal·2009

Related Experiment Video

Updated: Feb 8, 2026

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.6K

Hematopoietic Hierarchy - An Updated Roadmap.

Yifan Zhang1, Shuai Gao1, Jun Xia1

  • 1State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China; These authors contributed equally to this work.

Trends in Cell Biology
|June 25, 2018
PubMed
Summary
This summary is machine-generated.

Recent studies reveal that hematopoietic stem cells (HSCs) are more diverse than previously thought, challenging the classical roadmap. This review explores the heterogeneity of HSCs and their derivatives in development and adulthood.

Keywords:
hematopoietic hierarchyhematopoietic stem cellheterogeneitylineage biasnative and stress hematopoiesissingle cell

More Related Videos

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
11:16

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

8.1K
Homing of Hematopoietic Cells to the Bone Marrow
10:40

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

30.0K

Related Experiment Videos

Last Updated: Feb 8, 2026

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells
06:41

Isolation Method for Long-Term and Short-Term Hematopoietic Stem Cells

Published on: May 19, 2023

2.6K
Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
11:16

Preparation and Gene Modification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells

Published on: February 15, 2019

8.1K
Homing of Hematopoietic Cells to the Bone Marrow
10:40

Homing of Hematopoietic Cells to the Bone Marrow

Published on: March 18, 2009

30.0K

Area of Science:

  • Hematopoiesis research
  • Stem cell biology
  • Cellular heterogeneity

Background:

  • The classical hematopoietic hierarchy roadmap has been a long-standing dogma in stem cell research.
  • Recent technological advancements, including single-cell omics, have revealed significant heterogeneity within hematopoietic stem cells (HSCs) and their progeny.
  • This emerging understanding challenges the traditional, linear model of hematopoiesis.

Purpose of the Study:

  • To review recent advances in the field of hematopoiesis.
  • To provide an updated perspective on HSC heterogeneity.
  • To reflect on the complexity of HSCs and their derivatives during development and adulthood.

Main Methods:

  • Review of recent in vitro and in vivo studies.
  • Analysis of omics approaches at single-cell resolution.
  • Synthesis of current literature on hematopoiesis.

Main Results:

  • Evidence suggests that HSCs and their progeny exhibit considerable heterogeneity.
  • The classical hematopoietic hierarchy model may be an oversimplification.
  • New findings necessitate an updated view of hematopoiesis.

Conclusions:

  • Hematopoiesis is a more complex process than the classical roadmap suggests.
  • HSC heterogeneity is a key feature influencing development and adulthood.
  • An updated framework is needed to accurately represent HSC biology.