Related Experiment Video
Updated: Feb 8, 2026
08:42
Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex
Published on: February 8, 2020
11.3K
Visual brain plasticity induced by central and peripheral visual field loss.
Nicolae Sanda1,2,3,4,5, Leonardo Cerliani6,7,8,9, Colas N Authié10,11,12,13
1Sorbonne Universités, UPMC Université Paris 06, UMR S968, Institut de la Vision, 75012, Paris, France. herrsanda@gmail.com.
Brain Structure & Function
|June 25, 2018
Summary
Brain plasticity adapts to vision loss. Both central and peripheral vision impairment caused cortical thickness changes. Central vision loss uniquely increased cortical entropy in specific brain areas.
Area of Science:
- Neuroscience
- Ophthalmology
- Neuroimaging
Background:
- Visual deafferentation from central or peripheral vision loss offers insights into brain adaptation.
- Cortical changes are key indicators of neural plasticity in response to visual impairment.
Purpose of the Study:
- To investigate cortical adaptations in the brain following central or peripheral vision loss.
- To identify potential biomarkers of brain plasticity in visual field defects.
Main Methods:
- Cortical thickness (CoTks) and resting-state cortical entropy (rs-CoEn) were measured in patients with Stargardt macular dystrophy (central vision loss) and retinitis pigmentosa (peripheral vision loss).
- A control group of normally sighted subjects was included for comparison.
- Analysis focused on changes within the dorsal and ventral visual streams.
Main Results:
- Both visual loss groups showed decreased CoTks in dorsal area V3d compared to controls.
- Peripheral vision loss was associated with reduced CoTks in the early visual cortex and ventral area V4.
- Central vision loss showed reduced CoTks in dorsal area V3A and increased rs-CoEn in areas LO-2 and FG1.
Conclusions:
- Cortical thickness and entropy changes serve as biomarkers for brain plasticity in response to central and peripheral vision loss.
- Specific alterations in the dorsal and ventral visual streams are linked to the type of visual field defect.
Related Concept Videos
01:26Visual System
1.8K
Light enters the eye through the cornea, a transparent, dome-shaped surface covering the surface of the eyeball that helps to direct and focus incoming light. This light is then channeled toward the pupil, an adjustable opening whose size is controlled by the iris. The iris, a pigmented muscle, regulates the amount of light entering the eye by contracting or dilating the pupil, thereby ensuring optimal light levels for clear vision.
Once through the pupil, the light passes through the lens, a...
Once through the pupil, the light passes through the lens, a...
1.8K
01:09Peripherally and Centrally Acting Muscle Relaxants: A Comparison
4.6K
Skeletal muscle relaxants can target the central nervous system [CNS] to reduce muscle tension or act directly at the neuromuscular junction to induce temporary paralysis. These two classes of muscle relaxants are called centrally acting muscle relaxants and peripherally acting muscle relaxants. They differ in their action, mechanism, administration route, and clinical uses.
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
Centrally acting muscle relaxants can be further divided into spasmolytic and antispasmodic drugs. Spasmolytic...
4.6K
01:12Visual Agnosia
1.1K
Visual agnosia is a condition characterized by the inability to recognize visually presented objects despite having normal vision. For instance, a person with visual agnosia can describe the shape and color of an object but cannot identify or name it. This impairment does not affect their visual field, acuity, color vision, brightness discrimination, language, or memory. An example of this condition in a social setting is someone at a dinner party asking for "that silver thing with a round...
1.1K
01:23Induced Electric Fields
4.6K
The fact that emfs are induced in circuits implies that work is being done on the conduction electrons in the wires. What can possibly be the source of this work? We know that it’s neither a battery nor a magnetic field, as a battery does not have to be present in a circuit where current is induced, and magnetic fields never do any work on moving charges. The source of the work is in fact an electric field that is induced in the wires. For example, if a stationary conductor is placed in a...
4.6K
01:22Photoreceptors and Visual Pathways
9.3K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
9.3K
01:27Induced Electric Fields: Applications
2.7K
An important distinction exists between the electric field induced by a changing magnetic field and the electrostatic field produced by a fixed charge distribution. Specifically, the induced electric field is nonconservative because it does not work in moving a charge over a closed path. In contrast, the electrostatic field is conservative and does no net work over a closed path. Hence, electric potential can be associated with the electrostatic field but not the induced field. The following...
2.7K