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Tailored-BODIPY/Amphiphilic Cyclodextrin Nanoassemblies with PDT Effectiveness.

R Zagami1, G Sortino1, E Caruso2

  • 1CNR-ISMN c/o Dipartimento di Scienze Chimiche, Biologiche , Farmaceutiche ed Ambientali dell'Università di Messina , Viale F. Stagno d'Alcontres 31 , 98166 , Messina , Italy.

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|June 26, 2018
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Summary
This summary is machine-generated.

Amphiphilic cyclodextrins (aCDs) form nanoassemblies with BODIPY dyes for photodynamic therapy (PDT). These systems reduce dye aggregation and dark toxicity, showing potential for in vivo PDT applications.

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Area of Science:

  • Nanomedicine
  • Photochemistry
  • Organic Chemistry

Background:

  • Amphiphilic cyclodextrins (aCDs) are versatile carriers for therapeutic agents.
  • Photosensitizers (PSs) like BODIPY dyes are promising for photodynamic therapy (PDT).
  • PS aggregation reduces PDT efficacy and increases dark toxicity.

Purpose of the Study:

  • To develop and characterize nanoassemblies of amphiphilic cyclodextrins (aCDs) and iodinated BODIPY dyes for PDT.
  • To investigate the encapsulation and photophysical properties of BODIPY within aCD nanoassemblies.
  • To evaluate the cellular uptake, intracellular penetration, and photodynamic toxicity of the nanoassemblies.

Main Methods:

  • Preparation of BODIPY/aCD nanoassemblies (BL01I@SC6OH) via film evaporation, hydration, and sonication.
  • Characterization of nanostructures including hydrodynamic diameter, ξ-potential, and stability in biological media.
  • Investigation of BODIPY encapsulation using fluorescence spectroscopy and lifetime measurements.
  • Assessment of cellular uptake and phototoxicity in HCT116 cell lines.

Main Results:

  • BODIPY dyes were successfully encapsulated in a monomeric form within aCD nanoassemblies.
  • The nanoassemblies exhibited good stability in biological media.
  • BL01@SC6OH demonstrated efficient cellular uptake and intracellular penetration.
  • The photodynamically active BL01I/aCD nanoassembly showed toxicity upon irradiation, though free BL01I was more potent.

Conclusions:

  • Amphiphilic cyclodextrin-based nanoassemblies effectively encapsulate BODIPY dyes, preserving their properties.
  • These nanoassemblies show potential for modulating cell uptake and reducing dark toxicity in PDT applications.
  • Further development of aCD-BODIPY systems holds promise for in vivo photodynamic therapy.