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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Related Experiment Video

Updated: Feb 8, 2026

Author Spotlight: EasyFlow - An Economical and Adaptable Perfusion Bioreactor for Large Blood Vessel Culture
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The Vascularised Chamber as an In Vivo Bioreactor.

Kiryu K Yap1, George C Yeoh2, Wayne A Morrison3

  • 1O'Brien Institute, Department of St Vincent's Institute, Victoria, Australia; University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Victoria, Australia; Department of Plastic and Reconstructive Surgery, St Vincent's Hospital Melbourne, Victoria, Australia.

Trends in Biotechnology
|June 26, 2018
PubMed
Summary
This summary is machine-generated.

The vascularised tissue engineering chamber acts as an in vivo bioreactor, promoting blood vessel growth for tissue construct survival. This innovation is crucial for advancing regenerative medicine and cell therapies.

Keywords:
angiogenesisbioengineeringcell therapystem cellstissue engineeringtransplantationvascularised chamber

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Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Vascularization is essential for the survival and therapeutic efficacy of large tissue constructs.
  • Existing tissue engineering methods face challenges in achieving adequate vascularization for clinically relevant sizes.
  • Surgical techniques in tissue prefabrication and microsurgery provide a foundation for novel approaches.

Purpose of the Study:

  • To introduce and outline the concept of the vascularised tissue engineering chamber.
  • To explore its application in enhancing cell and tissue construct survival.
  • To discuss its potential role in future regenerative medicine and cell therapies.

Main Methods:

  • Surgically creating a closed, noncollapsible chamber around major blood vessels in vivo.
  • Utilizing the chamber as a protected space to promote an angiogenic environment.
  • Embedding the chamber within the body to serve as an in vivo bioreactor.

Main Results:

  • The chamber facilitates a highly angiogenic environment, crucial for tissue construct vascularization.
  • This approach supports the engraftment and survival of transplanted cells and engineered tissues.
  • The method leverages established surgical principles for in vivo tissue development.

Conclusions:

  • The vascularised tissue engineering chamber represents a significant advancement in tissue engineering.
  • It offers a promising strategy for overcoming vascularization challenges in regenerative medicine.
  • This technology has the potential to enable the development of larger, therapeutic tissue constructs.