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[Penile intra-epithelial neoplasia].
J N Dauendorffer1, C Renaud-Vilmer1, B Cavelier Balloy2
1Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Summary
Penile intraepithelial neoplasia (PIN) are precancerous lesions. Differentiating HPV-related from non-HPV-related PIN is crucial for appropriate urologist management, despite similar clinical presentations.
Area of Science:
- Urology
- Oncology
- Dermatology
Background:
- Penile intraepithelial neoplasia (PIN) comprises precancerous lesions of the genital epithelium.
- These lesions exhibit architectural and cytological abnormalities.
- PIN can progress to squamous cell carcinomas.
Purpose of the Study:
- To review the clinical and pathological characteristics of PIN.
- To emphasize treatment modalities for PIN.
- To highlight the importance of differentiating HPV-related and non-HPV-related PIN.
Main Methods:
- A literature review was conducted on the Medline database.
- Articles published between October 2007 and October 2017 were considered.
- Keywords included "intraepithelial neoplasia", "Bowen's disease", "erythroplasia of Queyrat", "bowenoid papulosis", and "penis".
Main Results:
- 174 articles related to PIN were identified, with 25 selected for relevance.
- An additional 6 relevant papers published before October 2007 were included.
- The review details clinical and pathological features and treatment options for PIN.
Conclusions:
- Urologists must differentiate between HPV-related and non-HPV-related PIN.
- Despite similar clinical presentations, distinct management strategies are required.
- Accurate diagnosis is essential for effective treatment of penile neoplasia.
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