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Chemo-enzymatic Synthesis of N-glycans for Array Development and HIV Antibody Profiling
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Hexvix plus Chemo.

Maximilian Burger1

  • 1Department of Urology, Caritas St. Josef Medical Centre, University of Regensburg, Germany.

European Urology Focus
|June 26, 2018
PubMed
Summary

Photodynamic diagnosis for bladder tumors is best for high-risk cases. Early chemotherapy is recommended for all low-risk cases, and potentially intermediate and high-risk cases based on new data.

Area of Science:

  • Urology
  • Oncology

Background:

  • Transurethral resection of bladder tumor (TURBT) is a standard procedure.
  • Risk stratification is crucial for optimizing bladder cancer management.
  • Photodynamic diagnosis (PDD) and intravesical chemotherapy are key treatment modalities.

Purpose of the Study:

  • To evaluate the optimal use of photodynamic diagnosis and intravesical chemotherapy in bladder tumor management.
  • To determine risk-based indications for PDD and chemotherapy following TURBT.

Main Methods:

  • Review of a recent randomized controlled trial comparing treatment strategies.
  • Analysis of outcomes based on tumor risk stratification (low, intermediate, high).

Main Results:

  • Photodynamic diagnosis during TURBT appears most warranted in high-risk bladder tumors.

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  • Early intravesical chemotherapy is indicated for all low-risk bladder tumors.
  • Emerging data suggests potential benefits of chemotherapy in intermediate- and high-risk cases.

    • Conclusions:

    • Risk stratification guides the application of PDD and intravesical chemotherapy after TURBT.
    • Current evidence supports PDD for high-risk cases and chemotherapy for low-risk cases.
    • Further research may expand the role of intravesical chemotherapy to intermediate and high-risk bladder cancer patients.