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Updated: May 13, 2026

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GPS1 Exon 9 Mutations Represent a Rare Genetic Event in Penile Squamous Cell Carcinoma Pathogenesis

Lars Tögel1,2,3,4,5, Felix Elsner1,2,3,4, Olaf Wendler2,4,6

  • 1Institute of Pathology, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.

International Journal of Molecular Sciences
|March 14, 2026
PubMed
Summary

Genetic analysis of penile squamous cell carcinoma (PSCC) investigated the GPS1 gene. While previously reported mutations were not found, two novel GPS1 alterations were identified, suggesting GPS1 exon 9 is targeted but unlikely an oncogenic driver in PSCC.

Keywords:
GPS1PSCCmolecular diagnosticspenile squamous cell carcinoma

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